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      <image:title>Blog 1 - CDISC U.S. Interchange 2025: Connecting Standards, Strategy, and the Future of Clinical Research - Make it stand out</image:title>
      <image:caption>CDISC CEO and President, Chris Decker, kicking off the CISC U.S. Interchange 2025 in Nashville, TN.</image:caption>
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      <image:title>Blog 1 - Regulatory Submissions with Real-World Evidence: Successes, Challenges, and Lessons Learned - Make it stand out</image:title>
      <image:caption>The four medical products using RWE as part of the submission and discussed in the morning sessions.</image:caption>
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      <image:title>Blog 1 - Optimizing Real-World Evidence Use at FDA, Workshop Insights - controlled trials (RCTs) at the top and observational studies lower down, but not the lowest. This pyramid, though foundational, is an oversimplification, Dr. Concato noted, and that while RCTs are more trustworthy, the interpretation that non-randomized studies are untrustworthy is incorrect. This blog author also wants to point out that observational studies still rank higher than anecdotes and personal opinions, which are the weakest level of evidence. The origins of the pyramid date back to 1976 when The Canadian Task Force on the Periodic Health Examination was established to determine how the periodic health examination might enhance or protect the health of the population.[4] This may be the topic of a future blog post.!</image:title>
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